【佳學(xué)基因檢測(cè)】解密ADRB1基因檢測(cè)結(jié)果，如何指導(dǎo)一個(gè)的健康？

基因檢測(cè)的序列名稱：

ADRB1

人體基因序列變化與疾病表征數(shù)據(jù)庫中的基因代碼：

153

人體基因序列數(shù)據(jù)庫中國際交流名稱全稱

adrenoceptor beta 1

中國數(shù)據(jù)庫中基因全稱：腎上腺素受體1基因檢測(cè)報(bào)告英文版基因簡(jiǎn)介

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

基因突變所影響的基因信息

腎上腺素受體（亞型α1，α2，β1和β2）是鳥嘌呤核苷酸結(jié)合調(diào)節(jié)蛋白偶聯(lián)受體的原型家族，其介導(dǎo)激素腎上腺素和神經(jīng)遞質(zhì)去甲腎上腺素的生理作用。該基因的特定多態(tài)性已顯示會(huì)影響靜息心率，并可能與心力衰竭有關(guān)。[由RefSeq提供，2008年7月]

國際國內(nèi)該堿基因序列的其他英語文字母簡(jiǎn)稱：

ADRB1R, B1AR, BETA1AR, RHR

基因解碼對(duì)該基因序列在細(xì)胞核中的染色體所給予的編號(hào)：

該基因序列位于人類第10號(hào)染色體上。

基因解碼對(duì)基因序列的正確定位

該基因序列在GRCh37版本中的起始位置坐標(biāo)為：115803806；結(jié)束位置坐標(biāo)為：115806667。該基因序列在GRCh38版本中的起始位置坐標(biāo)為：114044047；結(jié)束位置坐標(biāo)為：114046908。正確的基因信息定位是基因檢測(cè)和對(duì)檢測(cè)結(jié)果進(jìn)行正確解讀的關(guān)鍵。

佳學(xué)基因解碼對(duì)該基因的功能分類：國際版

G-protein coupled receptors/GPCRs excl olfactory receptors;Transporters

基因解碼對(duì)該基因的功能分類：中文版

G 蛋白偶聯(lián)受體/GPCR，不包括嗅覺受體；轉(zhuǎn)運(yùn)體

結(jié)構(gòu)與功能基因解碼所揭示的該基因在細(xì)胞內(nèi)發(fā)揮作用的場(chǎng)所（國際版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及明更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容

結(jié)構(gòu)與功能基因解碼所揭示的該基因發(fā)揮作用的細(xì)胞內(nèi)位置（中文版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及明更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容

該基因序列變化后增加的疾病風(fēng)險(xiǎn)（國際版）：

Ventricular Dysfunction; Endomyocardial Fibrosis; Hyperemia; Birth Weight; Cardiovascular Diseases; Cardiomyopathy, Dilated; Myocardial Reperfusion Injury; Diabetes Mellitus; Heart failure; Myocardial Ischemia; Mood Disorders; Mental Depression; Obesity; Hypertensive disease; Stomach Neoplasms; Depressive disorder

如果該基因突變后，風(fēng)險(xiǎn)可能增加的疾病類型（中文版）：

心室功能障礙；心內(nèi)膜心肌纖維化；充血;出生體重;心血管疾病;心肌病擴(kuò)張型；心肌再灌注損傷；糖尿?。恍呐K衰竭;心肌缺血；情緒障礙；精神抑郁癥；肥胖;高血壓病；胃腫瘤；抑郁癥

GWAS基因檢測(cè)所建立的與該基因的疾病關(guān)聯(lián)（國際版）：

Gaucher Disease;Blood Pressure

GWAS基因檢測(cè)所解碼的該基因突變會(huì)增加風(fēng)險(xiǎn)的疾病種類（中文版）：

戈謝??；血壓

以該基因做靶點(diǎn)的藥物（國際版）：

Amphetamine (Receptor signaling protein activity);Esmolol (Receptor signaling protein activity);Betaxolol (Receptor signaling protein activity);Bethanidine (Receptor signaling protein activity);Isoetarine (Receptor signaling protein activity);Cabergoline (Receptor signaling protein activity);Metoprolol (Receptor signaling protein activity);Amitriptyline (Receptor signaling protein activity);Olanzapine (Receptor signaling protein activity);Atenolol (Receptor signaling protein activity);Norepinephrine (Receptor signaling protein activity);Mirtazapine (Receptor signaling protein activity);Timolol (Receptor signaling protein activity);Phenylpropanolamine (Receptor signaling protein activity);Loxapine (Receptor signaling protein activity);Sotalol (Receptor signaling protein activity);Carteolol (Receptor signaling protein activity);Nortriptyline (Receptor signaling protein activity);Propranolol (Receptor signaling protein activity);Labetalol (Receptor signaling protein activity);Bisoprolol (Receptor signaling protein activity);Epinephrine (Receptor signaling protein activity);Trimipramine (Receptor signaling protein activity);Dobutamine (Receptor signaling protein activity);Pseudoephedrine (Receptor signaling protein activity);Alprenolol (Receptor signaling protein activity);Pindolol (Receptor signaling protein activity);Salbutamol (Receptor signaling protein activity);Isoprenaline (Receptor signaling protein activity);Arbutamine (Receptor signaling protein activity);Amiodarone (Receptor signaling protein activity);Carvedilol (Receptor signaling protein activity);Desipramine (Receptor signaling protein activity);Acebutolol (Receptor signaling protein activity);Nadolol (Receptor signaling protein activity);Levobunolol (Receptor signaling protein activity);Metipranolol (Receptor signaling protein activity);Fenoterol (Receptor signaling protein activity);Pirbuterol (Receptor signaling protein activity);Bevantolol (Receptor signaling protein activity);Practolol (Receptor signaling protein activity);Penbutolol (Receptor signaling protein activity);Ephedra (Receptor signaling protein activity);Mephentermine (Receptor signaling protein activity);Clenbuterol (Receptor signaling protein activity);Oxprenolol (Receptor signaling protein activity);Celiprolol (Receptor signaling protein activity);Dronedarone (Receptor signaling protein activity);Nebivolol (Receptor signaling protein activity);Asenapine (Receptor signaling protein activity);Droxidopa (Receptor signaling protein activity);Bufuralol (Receptor signaling protein activity);4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile (Receptor signaling protein activity);2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL (Receptor signaling protein activity);Bopindolol (Receptor signaling protein activity);Bupranolol (Receptor signaling protein activity);Vortioxetine (Receptor signaling protein activity)

針對(duì)該基因所產(chǎn)生的突變，可能有正確效果的藥物（中文版）：

安非他明（受體信號(hào)蛋白活性）;艾司洛爾（受體信號(hào)蛋白活性）;倍他洛爾（受體信號(hào)蛋白活性）;Bethanidine（受體信號(hào)蛋白活性）;異乙他林（受體信號(hào)蛋白活性）;卡麥角林（受體信號(hào)蛋白活性）;美托洛爾（受體信號(hào)蛋白活性);阿米替林(受體信號(hào)蛋白活性);奧氮平(受體信號(hào)蛋白活性);阿替洛爾(受體信號(hào)蛋白活性);去甲腎上腺素(受體信號(hào)蛋白活性);米氮平(受體信號(hào)蛋白活性);噻嗎洛爾(受體信號(hào)蛋白活性)蛋白活性);苯丙醇胺(受體信號(hào)蛋白活性);洛沙平(受體信號(hào)蛋白活性);索他洛爾(受體信號(hào)蛋白活性);卡替洛爾(受體信號(hào)蛋白活性);去甲替林(受體信號(hào)蛋白活性);普萘洛爾(受體信號(hào)蛋白活性) );拉貝洛爾（受體信號(hào)蛋白活性）;比索洛爾（受體信號(hào)蛋白活性）;腎上腺素（受體信號(hào)蛋白活性）;曲米帕明（受體信號(hào)蛋白活性）;多巴酚丁胺（受體信號(hào)蛋白活性）;偽麻黃堿（受體信號(hào)蛋白活性）; Alprenolol (Receptor signaling protein activity);吲哚洛爾(Receptor signaling protein activity);沙丁胺醇(Salbutamol)(Receptor signaling protein activity);異丙腎上腺素(Isoprenaline)(Receptor signaling protein activity);Arbutamine (Receptor signaling protein activity);胺碘酮(Receptor signaling protein activity);卡維地洛(Carvedilol)受體信號(hào)蛋白活性);地昔帕明(受體信號(hào)蛋白活性);醋丁洛爾(受體信號(hào)蛋白活性);納多洛爾(受體信號(hào)蛋白活性);左布洛爾(受體信號(hào)蛋白活性);美替洛爾(受體信號(hào)蛋白活性);非諾特羅(受體信號(hào)蛋白活性)蛋白活性);吡布特羅(受體信號(hào)蛋白活性);Bevantolol(受體信號(hào)蛋白活性);Practolol(受體信號(hào)蛋白活性);噴布洛爾(受體信號(hào)蛋白活性);麻黃(受體信號(hào)蛋白活性);美芬特明(受體信號(hào)蛋白活性) );瘦肉精（受體信號(hào)蛋白活性）;氧烯洛爾（受體信號(hào)蛋白活性）;賽力洛爾（受體信號(hào)蛋白活性）;決奈達(dá)?。ㄊ荏w信號(hào)蛋白活性）;奈必洛爾（受體信號(hào)蛋白活性）;阿塞那平（受體信號(hào)蛋白活性）;屈昔多巴（受體信號(hào)蛋白活性）；丁呋洛爾（受體信號(hào)蛋白活性）；4-{[(2S)-3-(叔丁基氨基)-2-羥丙基]氧基}-3H-吲哚-2-腈（受體信號(hào)蛋白activity);2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL (Receptor signaling protein activity);Bopindolol (Receptor signaling protein activity);Bupranolol (Receptor signaling protein activity);Vortioxetine (Receptor signaling protein activity)活動(dòng)）