【佳學(xué)基因檢測(cè)】CHRM1基因測(cè)試有突變會(huì)得什么??？

基因檢測(cè)的序列名稱：

CHRM1

人體基因序列變化與疾病表征數(shù)據(jù)庫(kù)中的基因代碼：

1128

人體基因序列數(shù)據(jù)庫(kù)中國(guó)際交流名稱全稱

cholinergic receptor muscarinic 1

中國(guó)數(shù)據(jù)庫(kù)中基因全稱：

膽堿能受體毒蕈堿1

基因檢測(cè)報(bào)告英文版基因簡(jiǎn)介

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

基因突變所影響的基因信息

毒蕈堿膽堿能受體屬于更大的G蛋白偶聯(lián)受體家族。這些受體的功能多樣性由乙酰膽堿的結(jié)合決定，包括細(xì)胞反應(yīng)，例如腺苷酸環(huán)化酶抑制，磷酸肌醇變性和鉀通道介導(dǎo)。毒蕈堿受體影響乙酰膽堿在中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)中的多種作用。毒蕈堿膽堿能受體1參與介導(dǎo)陰道誘發(fā)的支氣管收縮和胃腸道酸分泌。編碼該受體的基因位于11q13。[由RefSeq提供，2008年7月]

國(guó)際國(guó)內(nèi)該堿基基因序列的其他英語文字母簡(jiǎn)稱：

HM1, M1, M1R

基因解碼對(duì)該基因序列在細(xì)胞核中的染色體所給予的編號(hào)：

該基因序列位于人類第11號(hào)染色體上。

基因解碼對(duì)基因序列的正確定位

該基因序列在GRCh37版本中的起始位置坐標(biāo)為：62676151；結(jié)束位置坐標(biāo)為：62689012。該基因序列在GRCh38版本中的起始位置坐標(biāo)為：62908675；結(jié)束位置坐標(biāo)為：62921861。正確的基因信息定位是基因檢測(cè)和對(duì)檢測(cè)結(jié)果進(jìn)行正確解讀的關(guān)鍵。

佳學(xué)基因解碼對(duì)該基因的功能分類：國(guó)際版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解碼對(duì)該基因的功能分類：中文版

G 蛋白偶聯(lián)受體/GPCR 不包括嗅覺受體

結(jié)構(gòu)與功能基因解碼所揭示的該基因在細(xì)胞內(nèi)發(fā)揮作用的場(chǎng)所（國(guó)際版）：

Cytosol;Nucleus

結(jié)構(gòu)與功能基因解碼所揭示的該基因發(fā)揮作用的細(xì)胞內(nèi)位置（中文版）：

胞質(zhì)溶膠；細(xì)胞核

該基因序列變化后增加的疾病風(fēng)險(xiǎn)（國(guó)際版）：

Chronic schizophrenia; Memory Disorders; Brain Ischemia; Epilepsy; Seizures; Schizophrenia

如果該基因突變后，風(fēng)險(xiǎn)可能增加的疾病類型（中文版）：

慢性精神分裂癥；記憶障礙；腦缺血；癲癇;癲癇發(fā)作；精神分裂癥

GWAS基因檢測(cè)所建立的與該基因的疾病關(guān)聯(lián)（國(guó)際版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫(kù)的更新內(nèi)容

GWAS基因檢測(cè)所解碼的該基因突變會(huì)增加風(fēng)險(xiǎn)的疾病種類（中文版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫(kù)的更新內(nèi)容

以該基因做靶點(diǎn)的藥物（國(guó)際版）：

Cevimeline (Phosphatidylinositol phospholipase c activity);Succinylcholine (Phosphatidylinositol phospholipase c activity);Trospium (Phosphatidylinositol phospholipase c activity);Citalopram (Phosphatidylinositol phospholipase c activity);Oxyphenonium (Phosphatidylinositol phospholipase c activity);Benzatropine (Phosphatidylinositol phospholipase c activity);Ziprasidone (Phosphatidylinositol phospholipase c activity);Disopyramide (Phosphatidylinositol phospholipase c activity);Amitriptyline (Phosphatidylinositol phospholipase c activity);Ipratropium bromide (Phosphatidylinositol phospholipase c activity);Olanzapine (Phosphatidylinositol phospholipase c activity);Metixene (Phosphatidylinositol phospholipase c activity);Terfenadine (Phosphatidylinositol phospholipase c activity);Buclizine (Phosphatidylinositol phospholipase c activity);Clozapine (Phosphatidylinositol phospholipase c activity);Doxylamine (Phosphatidylinositol phospholipase c activity);Trihexyphenidyl (Phosphatidylinositol phospholipase c activity);Oxyphencyclimine (Phosphatidylinositol phospholipase c activity);Procyclidine (Phosphatidylinositol phospholipase c activity);Ethopropazine (Phosphatidylinositol phospholipase c activity);Loxapine (Phosphatidylinositol phospholipase c activity);Carbachol (Phosphatidylinositol phospholipase c activity);Promazine (Phosphatidylinositol phospholipase c activity);Hyoscyamine (Phosphatidylinositol phospholipase c activity);Cyproheptadine (Phosphatidylinositol phospholipase c activity);Pethidine (Phosphatidylinositol phospholipase c activity);Imipramine (Phosphatidylinositol phospholipase c activity);Methylscopolamine bromide (Phosphatidylinositol phospholipase c activity);Chlorpromazine (Phosphatidylinositol phospholipase c activity);Darifenacin (Phosphatidylinositol phospholipase c activity);Tridihexethyl (Phosphatidylinositol phospholipase c activity);Triflupromazine (Phosphatidylinositol phospholipase c activity);Anisotropine Methylbromide (Phosphatidylinositol phospholipase c activity);Nortriptyline (Phosphatidylinositol phospholipase c activity);Amoxapine (Phosphatidylinositol phospholipase c activity);Amoxapine (Phosphatidylinositol phospholipase c activity);Cinnarizine (Phosphatidylinositol phospholipase c activity);Atropine (Phosphatidylinositol phospholipase c activity);Nicardipine (Phosphatidylinositol phospholipase c activity);Pirenzepine (Phosphatidylinositol phospholipase c activity);Paroxetine (Phosphatidylinositol phospholipase c activity);Homatropine Methylbromide (Phosphatidylinositol phospholipase c activity);Trimipramine (Phosphatidylinositol phospholipase c activity);Scopolamine (Phosphatidylinositol phospholipase c activity);Benzquinamide (Phosphatidylinositol phospholipase c activity);Clidinium (Phosphatidylinositol phospholipase c activity);Propiomazine (Phosphatidylinositol phospholipase c activity);Propantheline (Phosphatidylinositol phospholipase c activity);Cryptenamine (Phosphatidylinositol phospholipase c activity);Dicyclomine (Phosphatidylinositol phospholipase c activity);Minaprine (Phosphatidylinositol phospholipase c activity);Tropicamide (Phosphatidylinositol phospholipase c activity);Biperiden (Phosphatidylinositol phospholipase c activity);Brompheniramine (Phosphatidylinositol phospholipase c activity);Flupentixol (Phosphatidylinositol phospholipase c activity);Cocaine (Phosphatidylinositol phospholipase c activity);Maprotiline (Phosphatidylinositol phospholipase c activity);Methantheline (Phosphatidylinositol phospholipase c activity);Cycrimine (Phosphatidylinositol phospholipase c activity);Cyclopentolate (Phosphatidylinositol phospholipase c activity);Glycopyrronium (Phosphatidylinositol phospholipase c activity);Tolterodine (Phosphatidylinositol phospholipase c activity);Oxybutynin (Phosphatidylinositol phospholipase c activity);Promethazine (Phosphatidylinositol phospholipase c activity);Pilocarpine (Phosphatidylinositol phospholipase c activity);Doxepin (Phosphatidylinositol phospholipase c activity);Flavoxate (Phosphatidylinositol phospholipase c activity);Desipramine (Phosphatidylinositol phospholipase c activity);Escitalopram (Phosphatidylinositol phospholipase c activity);Ketamine (Phosphatidylinositol phospholipase c activity);Quetiapine (Phosphatidylinositol phospholipase c activity);Diphenidol (Phosphatidylinositol phospholipase c activity);Metoclopramide (Phosphatidylinositol phospholipase c activity);Aripiprazole (Phosphatidylinositol phospholipase c activity);Chlorprothixene (Phosphatidylinositol phospholipase c activity);Methotrimeprazine (Phosphatidylinositol phospholipase c activity);Tiotropium (Phosphatidylinositol phospholipase c activity);Solifenacin (Phosphatidylinositol phospholipase c activity);Molindone (Phosphatidylinositol phospholipase c activity);Arecoline (Phosphatidylinositol phospholipase c activity);Mepenzolate (Phosphatidylinositol phospholipase c activity);NGX267 (Phosphatidylinositol phospholipase c activity);ALKS 27 (Phosphatidylinositol phospholipase c activity);ACP-104 (Phosphatidylinositol phospholipase c activity);Fesoterodine (Phosphatidylinositol phospholipase c activity);Aclidinium (Phosphatidylinositol phospholipase c activity);Umeclidinium (Phosphatidylinositol phospholipase c activity)

針對(duì)該基因所產(chǎn)生的突變，可能有正確效果的藥物（中文版）：

Cevimeline（磷脂酰肌醇磷脂酶 c 活性）；琥珀酰膽堿（磷脂酰肌醇磷脂酶 c 活性）；Trospium（磷脂酰肌醇磷脂酶 c 活性）；西酞普蘭（磷脂酰肌醇磷脂酶 c 活性）；氧酚（磷脂酰肌醇磷脂酶 c 活性）；苯扎托品（Phos磷脂酰肌醇磷脂酶 c 活性）；齊拉西酮（磷脂酰肌醇磷脂酶 c 活性);丙吡胺（磷脂酰肌醇磷脂酶 c 活性）;阿米替林（磷脂酰肌醇磷脂酶 c 活性）;異丙托溴銨（磷脂酰肌醇磷脂酶 c 活性）;奧氮平（磷脂酰肌醇磷脂酶 c 活性）;Metixene（磷脂酰肌醇itol 磷脂酶 c 活性）；特非那定（磷脂酰肌醇磷脂酶 c 活性）；布克利嗪（磷脂酰肌醇磷脂酶 c 活性）；氯氮平（磷脂酰肌醇磷脂酶 c 活性）；多西拉敏（磷脂酰肌醇磷脂酶 c 活性）；苯海索（磷脂酰肌醇磷脂酶 c 活性）；羥苯環(huán)亞胺（磷脂酰肌醇磷脂酶 c 活性）活動(dòng)）；丙環(huán)定（磷脂酰肌醇磷脂酶 c乙丙嗪（磷脂酰肌醇磷脂酶 c 活性）；洛沙平（磷脂酰肌醇磷脂酶 c 活性）；卡巴膽堿（磷脂酰肌醇磷脂酶 c 活性）；異丙嗪（磷脂酰肌醇磷脂酶 c 活性）；天仙子胺（磷脂酰肌醇磷脂酶 c 活性）；賽庚啶（磷脂酰肌醇磷脂酶 c 活性） ;哌替啶（磷脂酰肌醇磷脂酶 c 活性）；丙咪嗪（磷脂酰肌醇磷脂酶 c 活性）；甲基東莨菪堿溴化物（磷脂酰肌醇磷脂酶 c 活性）；氯丙嗪（磷脂酰肌醇磷脂酶 c 活性）；達(dá)非那新（磷脂酰肌醇磷脂酶 c 活性）；Tridihe xethyl（磷脂酰肌醇磷脂酶 c 活性）；三氟丙嗪（磷脂酰肌醇磷脂酶 c 活性）；異丙嗪甲基溴（磷脂酰肌醇磷脂酶 c 活性）；去甲替林（磷脂酰肌醇磷脂酶 c 活性）；阿莫沙平（磷脂酰肌醇磷脂酶 c 活性）；阿莫沙平（磷脂酰肌醇磷脂酶 c 活性）；Cin桂利嗪（磷脂酰肌醇磷脂酶 c 活性）；阿托品（磷脂酰肌醇磷脂酶 c 活性）；尼卡地平（磷脂酰肌醇磷脂酶 c 活性）；哌侖西平（磷脂酰肌醇磷脂酶 c 活性）；帕羅西?。字＜〈剂字?c 活性）；后馬托品甲基溴（磷脂酰肌醇磷脂酶 c 活性）；曲米帕明（磷脂酰肌醇磷脂酶 c 活性）磷脂酰肌醇磷脂酶 c 活性）；東莨菪堿（磷脂酰肌醇磷脂酶 c 活性）；Benzquinamide（磷脂酰肌醇磷脂酶 c 活性）；Clidinium（磷脂酰肌醇磷脂酶 c 活性）；Propiomazine（磷脂酰肌醇磷脂酶 c 活性）；Propantheline（磷脂酰肌醇磷脂酶 c 活性）；Cryptenamine（磷脂酰肌醇磷酸酶）脂肪酶 c 活性）；雙環(huán)胺（磷脂酰肌醇磷脂酶c活性);米那普林(磷脂酰肌醇磷脂酶c活性);托吡卡胺(磷脂酰肌醇磷脂酶c活性);比哌立登(磷脂酰肌醇磷脂酶c活性);溴苯那敏(磷脂酰肌醇磷脂酶c活性);氟哌噻噸(磷脂酰肌醇磷脂酶c活性);可卡因(磷脂磷脂酰肌醇磷脂酶c活性);馬普替林（磷脂酰肌醇磷脂酶 c 活性）;美沙林（磷脂酰肌醇磷脂酶 c 活性）;環(huán)辛胺（磷脂酰肌醇磷脂酶 c 活性）;環(huán)噴托酯（磷脂酰肌醇磷脂酶 c 活性）;格隆銨（磷脂酰肌醇磷脂酶 c 活性）;托特羅定（磷脂酰肌醇磷脂酶 c 活性）；奧昔布寧（磷脂酰肌醇磷脂酶 c 活性）；異丙嗪（磷脂酰肌醇磷脂酶 c 活性）；毛果蕓香堿（磷脂酰肌醇磷脂酶 c 活性）；多塞平（磷脂酰肌醇磷脂酶 c 活性）；黃酮（磷脂酰肌醇磷脂酶 c 活性）；地昔帕明（磷脂酰肌醇磷脂酰肌醇磷脂酶 c 活性）；艾司西酞普蘭（磷脂酰肌醇磷脂酶c活性);氯胺酮(磷脂酰肌醇磷脂酶c活性);喹硫平(磷脂酰肌醇磷脂酶c活性);地苯尼多(磷脂酰肌醇磷脂酶c活性);甲氧氯普胺(磷脂酰肌醇磷脂酶c活性);阿立哌唑(磷脂酰肌醇c活性)磷脂酶 c 活性）；氯丙噻吩（磷脂酰肌醇磷脂酶c活性);甲氧美拉嗪(磷脂酰肌醇磷脂酶c活性);噻托溴銨(磷脂酰肌醇磷脂酶c活性);索利那新(磷脂酰肌醇磷脂酶c活性);嗎啉酮(磷脂酰肌醇磷脂酶c活性);檳榔堿(磷脂酰肌醇磷脂酶c活性);甲哌佐酯(P磷脂酰肌醇磷脂酶c活性);NGX267（磷脂酰肌醇磷脂酶 c 活性）;ALKS 27（磷脂酰肌醇磷脂酶 c 活性）;ACP-104（磷脂酰肌醇磷脂酶 c 活性）;非索羅定（磷脂酰肌醇磷脂酶 c 活性）;阿地銨（磷脂酰肌醇磷脂酶 c 活性）;烏美克定ium（磷脂酰肌醇磷脂酶 c活動(dòng)）